Texas Screening Alliance for Cancer Therapeutics

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Texas Screening Alliance for Cancer Therapeutics

6100 Main, MS-141
Houston, Texas

(713) 396-6807

New Approaches to Natural Products-Based Drug Discovery for Cancer and Other Human Diseases

Natural products have been an excellent source of human medicines for centuries, originating with herbal remedies, and many are still being used today. Major advances in modern medicine and the pharmaceutical industry during the 19th and 20th centuries were driven by natural products and >50% of current therapeutics are either natural products or their derivatives. In spite of the success of natural products as a chemical resource for drug leads, during the last two decades the drug discovery industry has deemphasized or completely abandoned natural products-based drug discovery in favor of high throughput synthetic compound library screening and computational design of drug leads. However, the high expectations of a rich drug pipeline from synthetic compound library screening have not materialized. Many experts believe that the waning numbers of new chemical entities during the last decade may be a direct result of the deemphasis on natural products as leads for drug discovery. In the meantime, major technological breakthroughs including microscale analytical techniques for structure determination, advanced strategies and methods for total synthesis and structure-activity relationship studies of even highly complex natural products, advances in microbial genomics, accessing natural products from unculturable microorganisms via mega-genomic approaches and improved culturing strategies, engineering unnatural natural products via biocombinatorial chemistry, and novel approaches for natural product cellular target identification including genome wide target-based screening platforms leading to novel disease targets are all rapidly changing how we approach natural products-based drug discovery. This symposium will illustrate how these technological breakthroughs are leading to a renassiance of natural products chemistry, while discussing the challenges and opportunities in natural products drug discovery in the next decade and beyond.  

 Friday, October 12, 2012 from 8:00 AM to 5:00 PM
Continental breakfast and box lunches provided 

Texas A&M Health Science Center Institute of Biosciences and Technology
2121 W. Holcombe Blvd, Houston, Texas 77030
Validated parking at 2151 W. Holcombe, TMC Garage 8  

For wait list information email info@txsact.org

 Tentative Schedule 

Invited Speakers Include:
Zhiqiang An, Ph.D., University of Texas Health Science Center at Houston 
Joan Bennett, Ph.D., Rutgers University 
Gerald Bills, Ph.D., Medina, Spain 
Dale Boger, Ph.D., Scripps-La Jolla 
Jef DeBrabander,Ph.D., University of Texas Southwestern
Scott Gilbertson, Ph.D., University of Houston 
Frank Koehn, Ph.D., Pfizer 
Jun Liu, Ph.D., Johns Hopkins University 
Bruce Littlefield, Ph.D., Eisai Inc. 
Ted Molinski, Ph.D., University of California San Diego 
Susan Mooberry, Ph.D., University of Texas Health Science Center at San Antonio 
Dave Newmann, DPHIL, National Institutes of Health 
Daniel Romo, Ph.D., Texas A&M University 
Ben Shen, Ph.D., Scripps-Florida 

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